Submit-Pandemic Medical Drugs – Addressing Lengthy-COVID and Vaccine Accidents | NDNR

An evidence-informed, dysfunction-based strategy to evaluating spike protein results, comorbidities, coagulation abnormalities, immune dysregulation, and mitochondrial dysfunction.

Paul S. Anderson, NMD

Summary

This scientific replace summarizes a structured framework for assessing and managing Lengthy COVID and post-vaccination syndromes utilizing spike antibody monitoring, comorbidity stratification, and the Klok purposeful standing scale. It outlines tiered laboratory analysis and integrative therapeutic methods concentrating on coagulation, immune modulation, mitochondrial dysfunction, detoxing, and systemic irritation.

INTRODUCTION:

Addressing folks with Lengthy-COVID (LC) and Vaccine Accidents/Submit-Vaccination results (PV) are two growing scientific priorities in present medical follow.

In September 2025, NDNR revealed my overview of this subject https://ndnr.com/long-covid-vaccine-injuries-treatment/ as “Submit-Pandemic Medical Drugs: Addressing Lengthy-COVID and Vaccine Accidents”. This scientific abstract is instantly tied to that publication as nearly all of the scientific citations and element are contained in it.

The aim of this abstract is to “boil down” the evaluation and therapy stream set forth within the authentic publication.

NOTE: All references are discovered within the authentic publication, except specified within the textual content under.

ASSESSMENT AND INITIAL INTERVENTIONS:

For both LC or PV evaluation there are two broad strategies of evaluation, these being direct set off evaluation (Spike-protein, cytokines and so forth.) and whole-case comorbidity evaluation. Each will likely be outlined under.

First get hold of a baseline spike antibody degree.

1: BASELINE: Spike Protein / Cytokine Evaluation:

• SARS-CoV-2 Semi-Quantitative Complete Antibody, Spike [S-Protein, Semi-quant]
• SARS-CoV-2 Antibodies, Nucleocapsid [N-Protein, Qualitative]

Recall from the unique paper that the “N” protein is a marker of COVID an infection and could also be useful in differentiating infection-triggered versus vaccine-triggered spike ranges.

As outlined within the authentic paper, the extent of “S” protein differs between CV and PV shows. 

• COVID an infection triggers “S” rises to 500–800 U/mL and begins to fall after 90 days. 
• Vaccine induced “S” may be 800–1000 to over 25,000 U/mL and has been famous within the knowledge at 245 days.

Direct “SPIKE” Testing?

Direct “spike” testing will not be obtainable on the time of publication within the US, however within the authentic publication I record a supply in Europe which might detect S-Protein, Modified mRNA, and Plasmid-DNA.

Oblique Inflammatory Mediator Testing?

Some labs (referenced within the authentic publication) check particular person cytokines utilizing knowledge concerning cytokine-based pathophysiology of Lengthy COVID signs which will embody Il-1 collection, IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-g, and IL-17A.

Different publications advocate the next markers: Il 2, 4, 6, 8, 10, 13 GM-CSF, IFN-g, VEGF, (s)CD40l, CCL.

2: COMORBIDITY ASSESSMENT – Dysfunction Based mostly Evaluation and Remedy:

To evaluate the extent of dysfunction skilled by the affected person with LC or PV, a grading system needs to be employed. This enables the clinician to stratify their diagnostic and therapeutic strategy whereas prioritizing acceptable labs and different interventions.

Does it matter if one is assessing and treating PV or LC? In lots of senses, no. Because the situations are sometimes overlapping, and each have influences from comorbid situations past COVID or Spike protein, the strategy to evaluation and therapeutics can start in the identical place and be customized as required. A number of papers define the comorbidities of LC and PV syndromes. These embody endocrine deregulation, co-infections, coagulopathies, de-novo and aggravated autoimmunity, elevated sensitivity to environmental toxicants, potential for oncogenic processes, and lots of others.

The only and most clinically helpful scale for both LC or PV I’ve discovered was revealed by Klok et. al. Within the dialogue of assessments under. I’ll use this scale to stratify the scientific work-up particulars.

Graphic Under from: “Klok FA, Boon GJAM, Barco S, et al. The Submit-COVID-19 Useful Standing scale: a instrument to measure purposeful standing over time after COVID-19. Eur Respir J 2020; 56: 2001494”

A: Preliminary Historical past: LC or PV

• Present Sn/Sx and results on ADL (see the “Klok” scale above)
• Previous Historical past (lively or inactive):
  • CFS, FMS or different unexplained fatigue states
  • Power Infections, Inflammatory (PANS, CIRS…)
  • Autoimmunity or different Power Sickness
  • Power GI illness / syndromes
  • Most cancers
  • Ache syndromes, migraine and so forth.
  • Remedy for toxicity (mould, chemical, metallic)
  • Use of immunosuppressive therapies
  • Clotting Issues
  • Neuropsychiatric Historical past
  • Every other related pre-existing situation
  • COVID Vaccine, sort and quantity

Evaluation Targets: LC or PV

• Previous Historical past: Pertinent Constructive Findings
• Mitochondrial Harm
• Blood-Mind Barrier (BBB – Neuroinflammation
• Clotting
• Irritation
• Endocrine Dysregulation
• Infectious Brokers & Resistance Elements
• GI Dysregulation
• Toxins
• Genomics
• Hallmarks, indicators, or indications of occult or a recognized progressing most cancers.

B: Medical Dysfunction Based mostly Evaluation and therapy Concepts

Klok Asymptomatic Grade – 0

• Monitor fundamental labs: CBC, Ferritin, CMP-14, CRP, D-dimer, AlkPhos, LDH, CPK
• As a baseline: SARS-CoV-2 Semi-Quantitative Complete Antibody, Spike [S-Protein, Semi-quant]
• If assessing presence of antibodies from an infection: SARS-CoV-2 Antibodies, Nucleocapsid [N-Protein, Qualitative]
• Monitor any pre-existing irregular labs (i.e. HbA1C, Thyroid…)
• Rx: Train, Low Irritation Food plan, Centering/Meditation, Hydration
• Contemplate empiric anticoagulant therapies as clinically indicated:
  • Nattokinase, low dose 2000–3000 fibrinolytic items per day, on an empty abdomen (or different enzyme therapies).
  • Vitamin E 200–400 IU each day
  • Inclusion of anticoagulant assist is proposed based mostly on prior papers cited within the authentic publication in addition to the brand new knowledge revealed by Thierry, et.al.1
• Implement or preserve them on the essential dietary interventions:
  • Vit. A, D/K2, E; Vit. C, B-Advanced, Multimineral …
  • Deal with acute points PRN
  • Taper to baseline dietary supplements in 2-3 months 
  • Have them contact you if the state of affairs adjustments.

Klok Delicate Grade 1 – 2 

• The above listed “Klok Grade-0” labs and assessments plus:

• • Re-test any pre-existing situations 
  • Improve coagulopathy evaluation to incorporate D-dimer (quantitative), Fibrinogen exercise, Platelet Rely, PT-INR
    •  Expanded Thrombosis and Venous Danger Profiles could also be vital in additional superior circumstances and might embody:
      •  Anticardiolipin antibodies, IgG and IgM
      • Antithrombin exercise
      • β2-glycoprotein 1 antibodies, IgA, IgG, and IgM 
      • D-dimer
      • dRVVT display 
      • Issue II 
      • (prothrombin) mutation evaluation 
      • Issue V Leiden mutation evaluation
      • Protein C, purposeful 
      • Protein S antigen, free
  • Calculate Neutrophil/Lymphocyte ratio and comply with as a serial marker (larger NLR = worse irritation).73
  • Add: RBC Mineral Profile or at the least RBC Zn, Cu, Mg
  • Add: GGT; ANA with Reflex
  • Endo: rT3/Ft3/4, Thyroid Ab’s, TSH / AM Cortisol / Contemplate Estrogen / Progesterone / Testosterone
  • ID: ASO, Chlamydia and Mycoplasma pneumoniae., Candida, EBV, Complete Ig-G/M/A/E (others as clinically indicated – particularly if prior constructive.)
  • Unchallenged Urine Poisonous Metals (UTM) (norm values to NHANES)74, Contemplate Mycotoxin and Chemical toxin screening
  • Empiric therapies:
    • Deal with any abnormalities discovered on preliminary labs.
    • Anticoagulant therapies:
      • Nattokinase, low dose 4000–6000 fibrinolytic items per day on an empty abdomen (or different enzyme therapies).
      • Vitamin E 200–400 IU each day
      • Others as clinically indicated
    • Neurosteroids (low first-pass progesterone or pregnenolone). Use of micronized preparations in oil, sublingual drops or tablets, or troches. Doses of 100 to 200 mg nightly are frequent.
    • Immune-balancing:
      • Steadiness 25 (OH) and 1,25 (OH) Vitamin D3 ranges
      • Guarantee Vitamin D supplementation is balanced with Vitamin K2
      • Immune targeted mushroom therapies if indicated
      • Low Dose Naltrexone
      • Ivermectin 0.2 to 0.4 mg / kg [see notes in original paper.]
• Monitor q-2-4 weeks in comply with up

Klok Average Grade – 3

• All of the above listed labs and evaluation in “Klok Grade 0, 1, 2” plus:

• • Aggressively deal with Endo / ID / Poisonous and different trigger areas.
• Add on:
  • Different infectious screening: Lyme and Coinfections, Different Viruses, GI Testing for all infections
  • OAT (Natural Acids Check)
  • Submit problem UTM (you have already got a “pre” from above), Mycotoxin and Chemical Toxin screening
• Add on, if not already included:
  • Neurosteroid remedy and neuro restore / immunomodulatory immunotherapies, as famous above
  • LDN Rx.
  • Part-2 Biofilm Rx.
  • HBOT if they will acquire entry, both HBOT degree will work: 
    • 1.3 – 1.5 ATA 60-90 min with 3-4L O2 
    • or 2.0 – 2.75 ATA with O2 by masks 15L (may have air-break mid remedy) 2-5X per week initially.
    • Any COVID or Submit-COVID affected person would profit from HBOT
  • Different Rx. as indicated
    • Contemplate mitochondrial therapies as wanted akin to NAD, Methylene Blue, Purple / Close to IR Gentle Remedy, and so forth.
  • Monitor intently.

Klok Extreme Grade – 4 

• In my (and others) expertise you can not “section in” these peoples work up.
• A really essential have a look at any previous sickness or syndrome and follow-up is required.
• All areas listed for Endo, Tox, ID and so forth. have to be assessed and aggressively handled.
• The longer they’ve had LC or PV Sn/Sx and the extra previous / comorbidities, the longer wanted to deal with. However they’ll get higher if you’re aggressive.

C: Further Therapies:

 The above disfunction based mostly methods are the very best place to start out so far as evaluation and fundamental therapy are involved. All numeric references famous under are discovered within the authentic publication.

For each LC and PV the next areas are essential to contemplate:

1. Determine, Deal with, and Assist Comorbidities
2. Assist Clotting / Coagulation Points
3. Block Spike-protein from getting into cells
4. Degrade Spike-protein
5. Modulate Immune Perform
6. Assist Antioxidant and Nutrient Standing
7. Assist Mitochondrial Perform

Under are some therapeutic concepts which have repeatedly proven constructive outcomes throughout a big supplier group. This isn’t an exhaustive record however slightly interventions which have excessive therapeutic yield.

 1.Determine, Deal with, and Assist Comorbidities

The above part denoting the usage of the “Klok” scale and evaluation and therapeutic concepts covers this space properly.

Please be aware: If the comorbidities will not be addressed the therapeutics that comply with could have partial or momentary impact at finest. The therapeutics under assume underlying situations and comorbidities are being addressed. 

2. Assist Clotting / Coagulation Points

Coagulopathies are ubiquitous in LC and PV. Remedy ranges from therapies for apparent coagulopathy to empiric therapy for micro clotting. The main focus therapeutically within the prescription realm is issue Xa medication, heparin remedy, aspirin, clopidogrel, curcumin, and others. Within the pure remedy realm, enzymes, important fatty acids, vitamin E and others are frequent.

A typical scientific query is “can folks on issue Xa medication, heparin remedy, aspirin, clopidogrel, or a mixture of those use any pure anticoagulants?” The reply is mostly sure, as a result of the pure brokers under work in numerous elements of the clotting cascade. 

These are the next interventions generally used:

• Enzyme remedy is utilized in all sufferers. [I will use Nattokinase as an example but Lumbrokinase or Serratiopeptidase (also known as serrapeptase) can work as well. Also note that Lumbrokinase may have more effect if thrombi have already formed.] 112, 113
  • Nattokinase baseline dose is 2000 Models within the AM earlier than consuming
  • Nattokinase in larger threat folks may be dosed between 4000 and 10,000 Models each day.
• Vitamin E as blended tocopherols 200 to 400 IU each day 
• Omega-3 1000 to 2000 mg whole Omega-3 each day 114 – 116
• Curcumin is per week anticoagulant however a wonderful tissue protectant. If it clinically is suitable. 102 – 104
  • Completely different types of curcumin have completely different dose methods. I exploit Curcumin phytosome at 500 to 1000 mg per day
• In high-risk folks I’ll add 81 mg Aspirin each day (if they aren’t on it). 134

3. Bind Spike-protein and or Block from getting into cells

Ivermectin 84 – 88, in addition to quercetin 40, 107 – 111, curcumin 102 – 104, rutin 105, dandelion leaf 135, milk thistle 106, and Andrographis 136 – 138 are studied for this.

My follow has been to make use of Ivermectin at 0.2 to 0.4 mg / kg (rounded to the closest even quantity for prescribing ease) given in a single dose at night time, as it could actually have some GABA / somnolent impact. I dose this each day for 2 to 4 months as a base remedy after which see how they do if I cease the dose. In the event that they worsen when discontinuing the Ivermectin then they will return to the each day dose. It may be dosed long run till the individual has scientific remission. Security be aware: I’ve used Ivermectin in most cancers sufferers for over twenty years and it’s extremely secure if used long run.

I’ll usually add yet another pure agent. If they’re on curcumin that could be a good synergist. I sometimes add milk thistle 500 – 800 mg with dinner for this function but additionally to assist as a liver assist as properly. If “capsule rely overload” is a matter then curcumin can fill that twin function.

Moreover the flavonoid Rutin has some knowledge on Spike-protein binding.105

4. Degrade Spike-protein

Nattokinase is a subtilisin-like alkaline serine protease which has been proven to not solely be anticoagulant 112 but additionally degrade the Spike-protein 113. Different enzymes on this class probably have related results however nattokinase is the one at present with constructive knowledge. The above talked about dosing for anticoagulation may be ample. In sick people with excessive Spike antibodies I’ll usually guarantee the dose of nattokinase is 4000 – 10,000 Models each day away from meals for the primary three or extra months.

There’s a present dialogue of the potential of enzyme therapies aggravating these circumstances attributable to “incomplete breakdown” of the Spike-protein. Whereas this idea sounds intriguing if one seems to be on the knowledge on how utterly nattokinase breaks down Spike-protein it might seem this concern is unfounded.

Depuration and Cleansing

Depuration (entire physique supported elimination) and detoxing (particular pathway assist) clearly go hand in hand. The method of LC or PV sickness therapy will both instantly or not directly have these components concerned.

If a comorbidity of a toxin / toxicant presence is discovered then no matter particular therapies used for that comorbidity could also be sufficient to help. With or with out direct toxin / toxicant therapy each individual coping with LC or PV has a necessity for some degree of depuration and detoxing.

Choices (as clinically indicated) embody:

• Physique motion and hydration
• Warmth therapies
• Hydrotherapy of many sorts
• Excessive fiber meals and or binder sort dietary supplements
• Nutrient and antioxidant assist
• Particular therapies (chelation, oxidation, and so forth.)
• Blood filtration therapies:
  • Apheresis – Plasmapheresis / Therapeutic Plasma Change
  • Further-corporeal Blood Ozonation and Oxygenation (EBOO)
  • Plasma donation
  • Blood donation

5. Modulate Immune Perform

Each LC and PV are hallmarked by widespread immune deregulation. Some degree of immune modulation assist is critical as therapy progresses. If comorbid infections exist then this can be an extended course of. Many brokers already talked about above have immunomodulatory exercise (akin to curcumin, Ivermectin, milk thistle, and so forth.) however some additions I’ve seen useful are:

• Low Dose Naltrexone (LDN) dosed as in autoimmune circumstances 93-97
• Acute H-1 and H-2 blockers (MCAS comorbidity) 89 – 91
• Colchicine 0.5 or 0.6 mg BID for widespread irritation, particularly if vascular or cardiac comorbidity exists. 97 – 99 
• Melatonin. 101 Melatonin has the impact of circadian assist at decrease doses (1 – 10 mg) and likewise can act as a mitochondrial redox assist at larger (20 + mg) doses as properly.
• A mix acutely of Licorice 60 mg and Boswellia 200 mg given twice a day for fourteen days was additionally useful. 125 
  • Individually Licorice 120 – 124 and Boswellia 127 have knowledge as properly. 
• Optimizing Vitamin D ranges
• Different studied brokers embody:
  • Quercetin 40, 107 – 111
  • Luteolin 117 – 119 
  • Rutin 105 
  • Probiotics 131 – 134 
  • And Cinnamon, Clove, Ginger, Garlic, Thyme, Cardamom 139

6. Assist Antioxidant and Nutrient Standing

I cannot elaborate enormously on the necessity for assist of fundamental vitamin and antioxidant ranges within the LC and PV affected person. It’s properly documented in 139 and different assets for anybody needing a reference. There may be an extreme use of glutathione and vitamin C as water soluble antioxidants in all power sickness that needs to be addressed because the case progresses. 

7. Assist Mitochondrial Perform

Clinicians usually have their favourite “go to” mitochondrial helps already in use. If this space will not be addressed within the affected person with LC or PV the case will sometimes progress slowly, and affected person high quality of life will likely be low.

At all times guarantee that the essential components which usually assist the mitochondria and their operate are in place. Dietary and supplemental amino acids, hint minerals, iron, b-vitamins, and different fundamental vitamins are essential.

Acutely the next have been helpful in recovering power and likewise supporting different therapeutic pathways. These needs to be used inside their typical scientific tips for dose and security. A brief, however generally useful, record is:

• ALA, Co-Q10, and different “mitochondrial assist” mixtures
• NAD Assist which might embody IV NAD or NR, oral Niacinamide, and NR / NMN.
• Fasting 130
• Methylene Blue oral and or IV
• Purple – Close to IR Photodynamic Remedy
• FIR Sauna
• PEMF
• Hyperbaric Oxygen Remedy

Therapeutic Expectations:

In my expertise, it’s just like most complicated power sickness so far as the size of time and complexity of care required. These circumstances of LC and PV may be a number of the most troublesome a supplier will see. It does assist each the clinician and affected person to have a baseline “grading” utilizing the Klok scale as this could information depth of evaluation and therapies in addition to prognosticating the therapeutic trajectory. 

Estimated time to work on therapeutic are:

That is extra of a monitoring and prevention stage. If one finds a comorbidity on preliminary testing then which will prolong the time, however usually that is an preliminary evaluation, fundamental interventions and comply with up as required.

Relying on the comorbidities discovered these circumstances can begin to see some progress in weeks to months. Typically, progress could wax and wane however will likely be on an upward trajectory. Some sufferers really feel remarkably improved in six months and a few in two years. As for following laboratory values use typical comply with up intervals and let the affected person know why you repeat some labs kind of continuously. 

These sufferers sometimes have a number of comorbidities and require long run care and a spotlight. Some options could clear reasonably shortly (an instance being a thyroid situation discovered upon preliminary evaluation). Different options, particularly aggravated or new autoimmunity, toxicity, and so forth. could also be very long run points. In lots of circumstances these long run points are extra power administration objects with the objective to enhance general operate and high quality of life slightly than reaching a “full treatment”. 

• Word concerning utilizing the Spike Antibody as baseline talked about above: I usually don’t check that extra continuously than each six months. Symptomatic enchancment is extra essential than Spike Antibody drop. One correlation nonetheless to persistently elevated Spike Antibodies is the necessity to proceed the Spike blocking, degrading, and anticoagulation therapies (as famous above) no matter symptom enchancment.

Elements which delay therapeutic trajectory:

• Issues that “didn’t appear like they wanted to be checked”:
  • Some frequent ones embody rT3, Cortisol, reproductive hormones, toxin-toxicants together with chemical, metallic and mycotoxins. Autoimmunity and Infections, particularly if not current prior.
• Not re-checking and adjusting acute use therapies:
  • Endocrine, GI, Infectious, Poisonous, and so forth.
• Typically, not following up on and treating pertinent positives from previous labs or new findings.
• Not appreciating the impression of long-term manufacturing of Spike from the mRNA vaccines, or the impression of COVID reinfection.

 

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Paul S. Anderson, NMD, is a licensed naturopathic doctor with over three many years of scientific expertise in complicated power sickness, infectious illness, immune dysregulation, and integrative oncology. A graduate of the Nationwide College of Pure Drugs (NUNM), Dr. Anderson has served as a medical director and educator throughout a number of establishments and is well known for his experience in combining typical and naturopathic therapeutics in medically complicated sufferers.

He’s the founding father of Anderson Medical Specialty Associates and a frequent worldwide lecturer on subjects together with power infections, IV therapeutics, environmental drugs, mitochondrial dysfunction, and superior case administration. Dr. Anderson has authored quite a few instructional applications and publications for healthcare professionals and is thought for translating rising analysis into structured, clinically actionable protocols that emphasize affected person security and systems-based care.

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Unique References may be discovered right here: https://ndnr.com/long-covid-vaccine-injuries-treatment/

Further References for this paper:

1. Thierry AR, Usher T, Sanchez C, Turner S, Venter C, Pastor B, Waters M, Thompson A, Mirandola A, Pisareva E, Prevostel C, Laubscher GJ, Kell DB, Pretorius E. Circulating Microclots Are Structurally Related With Neutrophil Extracellular Traps and Their Quantities Are Elevated in Lengthy COVID Sufferers. J Med Virol. 2025 Oct;97(10):e70613. doi: 10.1002/jmv.70613. PMID: 41036702; PMCID: PMC12489976.