CONFERENCE REPORTER
In the US, an estimated 21 million adults have had not less than 1 main depressive dysfunction (MDD) episode.1 Selective serotonin reuptake inhibitors, whereas extremely efficient in some people with MDD, are solely partially efficient or ineffective in as much as 50% of sufferers.2
David Medina, MD, FAPA, introduced his session, “Breaking Boundaries within the Administration of Therapy-Resistant and Tough-to-Deal with Despair,” on the Southern Florida Psychiatry Convention in West Palm Seashore, Florida.
As a part of his presentation, Medina mentioned the “neuroplasticity speculation,” a brand new mind-set about melancholy that “could present a greater framework for clarification the pathogenesis of MDD and antidepressant efficacy.”3
“The mainstream understanding of melancholy and the way antidepressants work remained the identical for roughly 50 years. It was centered on monoaminergic system,” stated Medina.
New medicines like ketamine have a fast onset of motion. “Generally you may see ends in hours. This is essential as a result of melancholy is the main reason for incapacity and suicidality,” shared Medina.
Dr Medina is the president, medical director, and principal investigator at Nova Psychiatry, in Orlando, FL.
References
1. Main melancholy. Nationwide Institute of Psychological Well being. Accessed December 2, 2025.
2. Rush AJ, Trivedi MH, Wisniewski SR, et al.
3. Liu B, Liu J, Wang M, et al.