Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured affiliate professor within the Division of Molecular Pharmacology and Physiology on the College of South Florida Morsani Faculty of Drugs and a Visiting Senior Analysis Scientist on the Institute for Human and Machine Cognition.
He teaches medical neuroscience, physiology, diet, and neuropharmacology, and his analysis focuses on the event and testing of dietary methods and metabolic-based therapies for neurological problems, most cancers, and human efficiency optimization. His work spans each fundamental science and human scientific trials.
He has a robust private curiosity in environmental drugs and enhancing the protection and resilience of army personnel and astronauts. On this capability, he served as a analysis investigator and crew member on NASA’s Excessive Atmosphere Mission Operations. His analysis has been supported by the Workplace of Naval Analysis, the Division of Protection, the Nationwide Institutes of Well being, personal organizations, and nonprofit foundations.
He earned his B.S. in Dietary Science and Organic Sciences from Rutgers College in 1998, adopted by a predoctoral fellowship in Neuroscience and Physiology at Rutgers and the College of Drugs and Dentistry of New Jersey. He then accomplished postdoctoral coaching in Neuroscience at Wright State College’s Boonshoft Faculty of Drugs in 2004 and at College of South Florida Morsani Faculty of Drugs in 2006.
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Dr. Dominic D’Agostino — All Issues Ketones, How one can Shield the Mind and Enhance Cognition, Sardine Fasting, Weight loss program Guidelines, Revisiting Metformin and Melatonin, and Extra
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SELECTED LINKS FROM THE EPISODE
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KetoNutrition.org | Fb | Twitter | College of South Florida
Dr. Dominic D’Agostino’s Previous Appearances
Ideas & Concepts
- APOE3/4 Genotype: A genetic variant the place people carry one copy every of the APOE3 and APOE4 alleles, related to reasonably elevated threat of Alzheimer’s illness in comparison with APOE3/3 however decrease threat than APOE4/4.
- Kind 3 Diabetes: A time period used to explain Alzheimer’s illness as a type of insulin resistance and insulin deficiency that happens particularly within the mind, characterised by impaired neuronal glucose metabolism.
- The 4 Horsemen of Power Illness: The 4 pillars of continual illness, in accordance with Dr. Peter Attia.
- Glucose Hypometabolism: A state the place the mind’s skill to make use of glucose for vitality is impaired, usually occurring greater than 10 years earlier than the onset of Alzheimer’s illness signs and thought of a key characteristic of neurodegeneration.
- Neuroinflammation: Irritation of nervous tissue involving activation of microglia and astrocytes, thought-about a significant driver of neurodegenerative illnesses together with Alzheimer’s, Parkinson’s, and a number of sclerosis.
- Ketogenic Weight loss program: A really low-carbohydrate (sometimes beneath 50g per day), high-fat weight-reduction plan initially developed at Mayo Clinic within the Nineteen Twenties to deal with epilepsy, which forces the physique to provide ketones for gasoline as an alternative of utilizing glucose.
- Mediterranean-Model Low-Carb Weight loss program: A modified model of the normal Mediterranean weight-reduction plan that reduces carbohydrate consumption whereas emphasizing greens, fish, olive oil, nuts, and wholesome fat to help weight reduction and blood sugar management.
- Exogenous Ketones: Ketone our bodies (primarily beta-hydroxybutyrate) which might be consumed by way of dietary dietary supplements within the type of ketone salts, esters, or precursor compounds, permitting for speedy elevation of blood ketones with out dietary restriction.
- Ketone Monoester vs. Diester vs. Salts: Totally different types of exogenous ketone dietary supplements the place monoesters present essentially the most environment friendly ketone elevation, diesters are bonds between two ketone molecules, and salts mix ketones with minerals like sodium or potassium.
- Glucose Ketone Index (GKI): A ratio calculated by dividing blood glucose ranges by ketone ranges, used as a biomarker for metabolic well being and the depth of ketosis, with decrease values indicating higher metabolic flexibility.
- Fasting and “Sardine Fasting”: Abstaining from meals for therapeutic advantages, with “sardine fasting” referring to a modified fasting method the place solely sardines are consumed, offering protein whereas sustaining some advantages of fasting.
- Autophagy: The physique’s mobile recycling strategy of cleansing out broken organelles and proteins to regenerate newer, more healthy mobile parts, enhanced during times of fasting and ketosis.
- Most cancers Cachexia: A posh metabolic syndrome characterised by extreme lack of muscle mass and physique weight, usually accompanied by anemia, weak spot, and lack of urge for food in most cancers sufferers.
- Metabolic Psychiatry: An rising discipline that makes use of metabolic interventions, notably ketogenic diets and exogenous ketones, to deal with psychological well being situations by addressing underlying metabolic dysfunction within the mind.
- NLRP3 Inflammasome: A multiprotein complicated in immune cells that acts as a mobile sensor and triggers inflammatory responses, enjoying an important position in innate immunity and implicated in varied neurodegenerative illnesses.
- Metabolic Management of Epigenetic Regulation: The idea that metabolites like beta-hydroxybutyrate can instantly affect gene expression by appearing as signaling molecules and histone deacetylase inhibitors, affecting mobile perform and well being.
- Redox Stress: An imbalance within the mobile ratio of NAD+ to NADH that may impair mitochondrial perform and vitality manufacturing, usually related to getting old and metabolic dysfunction.
- Hyperbaric Oxygen Remedy (HBOT): A medical remedy involving respiration pure oxygen in a pressurized chamber at 1.5 to three instances regular atmospheric stress, used to reinforce therapeutic and deal with varied situations together with wound therapeutic and carbon monoxide poisoning.
- Lipid Vitality Mannequin: A metabolic mannequin explaining how LDL ldl cholesterol and ApoB particles might be elevated on low-carbohydrate diets as they perform as transport automobiles for mobilized fatty acids used for vitality manufacturing.
- SARM (Selective Androgen Receptor Modulator): A category of therapeutic compounds designed to selectively bind to androgen receptors in particular tissues, doubtlessly providing the muscle-building advantages of anabolic steroids with diminished androgenic unintended effects.
Substances & Medication
- Beta-Hydroxybutyrate (BHB): The first ketone physique produced throughout fats metabolism and ketosis, used in its place vitality supply for the mind and physique.
- 1,3-Butanediol: A ketone precursor and alcohol compound that’s metabolized into beta-hydroxybutyrate (BHB) within the liver.
- MCT Oil (Medium-Chain Triglyceride): A sort of saturated fats that’s readily absorbed and transformed into ketones, generally utilized in ketogenic diets.
- Creatine Monohydrate: A complement that helps regenerate ATP in muscle mass, identified for enhancing train efficiency, power, and doubtlessly cognitive perform.
- Lipopolysaccharide (LPS): A element of gram-negative bacterial cell partitions utilized in analysis to induce systemic irritation and examine immune responses.
- Ezetimibe (Zetia): A prescription remedy that lowers ldl cholesterol by inhibiting its absorption within the small gut.
- Rapamycin: An immunosuppressive drug initially used to stop organ rejection that has gained consideration for potential anti-aging and longevity results.
- Metformin: A primary-line remedy for kind 2 diabetes that lowers blood glucose ranges and has potential advantages for longevity and metabolic well being.
- Berberine/Dihydroberberine: Plant-derived alkaloid compounds with glucose-lowering results much like metformin, used for metabolic well being help.
- GLP-1 Agonists: A category of diabetes medicines that mimic incretin hormones to control blood sugar and promote weight reduction, together with medicine like semaglutide and tirzepatide.
- SGLT-2 Inhibitors: A category of diabetes medicines that decrease blood sugar by stopping glucose reabsorption within the kidneys, inflicting extra glucose to be excreted in urine.
- NAD Dietary supplements: Dietary supplements like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) designed to spice up mobile NAD+ ranges for potential anti-aging advantages.
- Idebenone / CoQ10 / Ubiquinol: Antioxidant compounds that help mitochondrial vitality manufacturing and mobile well being, with CoQ10 being important for ATP synthesis.
- GABA / Phenibut: Gamma-aminobutyric acid and associated compounds which have calming, inhibitory results on the central nervous system.
- Diphenhydramine (Benadryl): An over-the-counter antihistamine generally used for allergic reactions that causes drowsiness and is typically used as a sleep assist.
- Melatonin: A hormone naturally produced by the pineal gland that regulates the sleep-wake cycle and is often used as a sleep complement.
- Ostarine: A selective androgen receptor modulator (SARM) that selectively targets muscle and bone tissue, talked about for veterinary use in analysis contexts.
- Alpha GPC / Theanine: Nootropic compounds the place Alpha-GPC helps acetylcholine manufacturing for cognitive perform and L-theanine promotes leisure with out sedation.
Merchandise & Manufacturers
- KetoStart (Audacious Diet): A ketone electrolyte complement firm based by Dr. Dominic D’Agostino’s spouse, specializing in exogenous ketone merchandise.
- Qitone: A model that produces ketone diester powder dietary supplements for enhancing ketosis and metabolic efficiency.
- Keto-Mojo: An organization that manufactures moveable blood glucose and ketone testing units in style amongst these following ketogenic diets.
- Abbott Precision Xtra: A dual-purpose blood glucose and ketone monitoring system manufactured by Abbott for diabetes administration and ketosis monitoring.
- LMNT: An electrolyte complement model that gives sugar-free, keto-friendly hydration merchandise with optimum sodium, potassium, and magnesium ratios.
- Ranges: A metabolic well being firm that gives steady glucose screens (CGMs) paired with an app to assist customers optimize their blood sugar responses.
- Stelo: An over-the-counter steady glucose monitor developed by Dexcom for individuals with out diabetes to trace their glucose patterns.
- GB HealthWatch: A genetic testing firm that gives customized studies for dyslipidemia and cardiovascular threat evaluation primarily based on DNA evaluation.
- Dry Farm Wines: A wine firm specializing in pure, low-sugar, additive-free wines which might be lab-tested for purity and decrease alcohol content material.
- French Girls Don’t Get Fats: The Secret of Consuming for Pleasure by Mireille Guiliano: A bestselling way of life information that reveals the “French paradox” of how French girls keep slim whereas having fun with bread, wine, and three-course meals by way of ideas of steadiness, high quality over amount, and consuming for pleasure fairly than restriction.
- Keto Brainz: A complement model that produces MCT powder enhanced with nootropic compounds to help each ketosis and cognitive perform.
- Nutricost / Quest: Fashionable complement manufacturers that supply MCT powder merchandise amongst their intensive product strains.
- Nordic Naturals: A premium omega-3 complement model identified for high-quality fish oil merchandise with third-party purity testing and sustainable sourcing.
- OmegaQuant: A testing firm that measures omega-3 fatty acid ranges in blood to assist people optimize their omega-3 standing and cardiovascular well being.
- Metabolic Thoughts: An academic platform from the Baszucki Group that focuses on metabolic approaches to psychological well being and psychiatric situations.
- MetPsy: An app at the moment in improvement designed to offer metabolic remedy teaching and help for psychological well being purposes.
Establishments
- NIH (Nationwide Institutes of Well being): The first company of the US authorities answerable for biomedical and public well being analysis.
- USF (College of South Florida): Public analysis college in Tampa the place Dr. D’Agostino is a professor.
- Byrd Alzheimer’s Middle: Analysis institute at USF Well being devoted to Alzheimer’s illness prevention, remedy and remedy the place Dr. D’Agostino’s spouse labored.
- Buck Institute for Analysis on Growing old: Unbiased biomedical analysis institute in California centered on extending wholesome years of life.
- Harvard College: Non-public Ivy League analysis college in Cambridge, Massachusetts the place Chris Palmer and Georgia Ede are affiliated.
- Moffitt Most cancers Middle: Nationwide Most cancers Institute-designated complete most cancers heart in Tampa collaborating with Dr. D’Agostino.
- Stanford College: Non-public analysis college in California the place Shebani Sethi is affiliated.
- Oxford College: Prestigious collegiate analysis college in England the place Dr. Ally Houston is affiliated.
- Northwestern College: Non-public analysis college in Illinois the place Dr. Nav Chandel conducts analysis.
- College of Edinburgh: Public analysis college in Scotland the place Dr. Iain Campbell conducts analysis.
- Yale College: Non-public Ivy League analysis college in Connecticut the place Dr. Deep Dixit is a researcher.
- Genentech: American biotechnology company and subsidiary of Roche, pioneering in recombinant DNA expertise.
- Metro Worldwide Biotech: Scientific-stage pharmaceutical firm creating NAD+ precursors and therapeutics like MIB-626.
Related Assets & Analysis
Individuals
- Mary Newport: Doctor and creator who pioneered the usage of MCT oil for Alzheimer’s illness, founding medical director of new child intensive care items in Florida.
- Steve Newport: Husband of Dr. Mary Newport, topic of a case report on utilizing a ketone monoester for Alzheimer’s illness who skilled important enhancements.
- Sam Corcos: Co-founder and CEO of Ranges, a well being expertise startup that makes use of steady glucose screens to assist individuals perceive how meals impacts their metabolic well being.
- Richard Veech: NIH researcher who developed the beta-hydroxybutyrate monoester and studied ketones for cognitive decline and neurological problems.
- Peter Attia: Doctor and longevity professional, identified for the “4 Horsemen” idea, host of The Drive podcast and creator of the #1 New York Occasions bestseller Outlive.
- George F. Cahill Jr.: Scientist identified for his historic fasting research and analysis on metabolic physiology at Harvard Medical Faculty.
- Thomas Seyfried: Professor and most cancers researcher at Boston Faculty, colleague of Dr. D’Agostino who research metabolic approaches to most cancers remedy.
- Fred Hatfield (“Dr. Squat”): Powerlifter and mentor to Dr. D’Agostino who used a ketogenic weight-reduction plan for metastatic prostate most cancers remedy.
- Valter Longo: Researcher identified for the Fasting Mimicking Weight loss program and director of the USC Longevity Institute finding out getting old and illness prevention.
- Mike Dancer: Man whose expertise with epilepsy and the ketogenic weight-reduction plan influenced Dr. D’Agostino’s analysis path.
- Sam Henderson: Researcher who printed early analysis on AC-1202 (MCT oil) for Alzheimer’s illness remedy.
- Jong Rho: Researcher who highlighted the significance of acetoacetate and acetone in seizure management mechanisms.
- Spencer Nadolsky: Doctor who prompt Dr. D’Agostino may be a hyperabsorber of ldl cholesterol primarily based on his lipid profiles.
- Matt Kaeberlein: Growing old researcher and professor on the College of Washington finding out longevity and healthspan extension.
- Csilla Ari D’Agostino: Neuroscientist, Dom’s spouse, and founding father of Audacious Diet.
- Charles Poliquin: Late power coach identified for his progressive coaching strategies and work with elite athletes worldwide.
- Dale Bredesen: Doctor and researcher centered on Alzheimer’s illness remedy and prevention by way of the ReCODE protocol.
- Navdeep Chandel: Researcher at Northwestern College finding out mobile metabolism and its position in well being and illness.
- Andrew Huberman: Neuroscientist and professor at Stanford College, host of the favored Huberman Lab podcast on well being and efficiency.
- Rhonda Patrick: Scientist and host of FoundMyFitness, specializing in diet, getting old, and illness prevention by way of way of life interventions.
- Eric Verdin: President and CEO of the Buck Institute for Analysis on Growing old, finding out metabolism and getting old processes.
- Vishwa Deep Dixit: Researcher at Yale College who studied the NLRP3 inflammasome and its position in metabolic well being.
- Chris Palmer: Harvard psychiatrist and creator of Mind Vitality, advocate for metabolic psychiatry approaches to psychological well being remedy.
- Matt Baszucki: Son of David Baszucki, whose expertise with bipolar dysfunction was handled with a ketogenic weight-reduction plan method.
- Jan and David Baszucki: Founders of Roblox, philanthropists funding metabolic psychiatry analysis by way of the Baszucki Mind Analysis Fund.
- Shebani Sethi: Psychiatrist at Stanford College researching metabolic approaches to psychological well being remedy.
- Ally Houston: Researcher at Oxford College finding out metabolism and mind perform.
- Georgia Ede: Harvard-trained psychiatrist and creator of Change Your Weight loss program, Change Your Thoughts, specializing in dietary psychiatry.
- Iain Campbell: Researcher on the College of Edinburgh finding out bipolar dysfunction and metabolic interventions.
- Deanna Tedone: Particular person with ALS who stabilized her situation utilizing the “Deanna Protocol” dietary method.
- Angela Poff and Victoria Area: Colleagues of Dr. D’Agostino who run the Metabolic Well being Initiative on the College of South Florida.
SHOW NOTES
- [00:00:00] Begin.
- [00:14:43] Why I’m interested by ketogenic methods for neurodegenerative prevention.
- [00:16:18] Mary and Steve Newport’s ketone-linked short-term cognitive enhancements.
- [00:18:18] A mechanisms overview for Alzheimer’s/dementia.
- [00:21:25] The immune system as longevity’s “fifth horseman” — and why metabolic management is essential.
- [00:22:04] How one can measure ketones and GKI.
- [00:23:00] Fasting vs. ketogenic weight-reduction plan.
- [00:24:18] There’s nothing fishy about sardine fasting.
- [00:28:32] My hiatal hernia discovery and elevated most cancers threat considerations.
- [00:30:04] HSCRP as a superior biomarker to LDL for cardiovascular threat.
- [00:31:57] Glucose tolerance testing revelations and CGM significance.
- [00:31:57] Upgrading the metabolic equipment by way of keto with out losing interest.
- [00:42:07] What do do in the event you, like Dom and me, are among the many 30% that suffer from ldl cholesterol hyperabsorption.
- [00:43:42] Dom’s day-to-day weight-reduction plan routine.
- [00:45:56] How Dom optimizes his getting old canines with ketones, SARMs, and dietary supplements.
- [00:51:30] Supplementing for sleep disruption whereas fasting.
- [00:55:41] Why Dom doesn’t have misgivings about melatonin.
- [00:59:15] Shingles prevention by way of fasting protocols.
- [01:00:15] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.
- [01:03:54] Dom at 50-something: Present meal timing and composition.
- [01:05:57] Blue zone observations: Greek and Sardinian longevity habits.
- [01:08:16] Ketogenic weight-reduction plan initiation ideas: MCT, electrolytes, and fasted cardio.
- [01:15:18] Ketone metabolic remedy for most cancers.
- [01:18:15] The metabolic psychiatry revolution.
- [01:22:10] The soothing results of hyperbaric oxygen and ketosis on seizure victims.
- [01:28:27] Metformin vs. berberine.
- [01:31:43] The low-dose neuroprotective potential of GLP-1 medicine.
- [01:34:58] NAD analysis: MIB-626 and stabilized varieties for mitochondrial well being.
- [01:39:48] Idebenone, CoQ10, and the Deanna protocol for ALS.
- [01:42:05] Dom’s complement quick checklist: CoQ10, creatine, ketones, vitamin D, melatonin.
- [01:44:43] KetoNutrition.org, Metabolic Well being Summit, Audacious Diet, veteran-focused analysis protocols, and different parting ideas.
DR. DOMINIC D’AGOSTINO QUOTES FROM THE INTERVIEW
“I feel the fantastic thing about ketogenic [therapy] is that it’s pleiotropic, proper? Which implies it’s many mechanisms working in synergy.”
— Dr. Dominic D’Agostino
“I feel the easiest way to measure to recommend you’re in autophagy is a glucose ketone index after a interval of fasting.”
— Dr. Dominic D’Agostino
“About 30 p.c of the inhabitants hyperabsorbs ldl cholesterol.”
— Dr. Dominic D’Agostino
“HSCRP is a greater indicator of heart problems than LDL ldl cholesterol. We all know that now. [No one would believe it] If somebody mentioned that 10 years in the past.”
— Dr. Dominic D’Agostino
“I wouldn’t go above three, most likely 1.5 to 2 millimolar vary. That appears to be a stage of ketones that safely doesn’t produce a metabolic acidosis.”
— Dr. Dominic D’Agostino
“Once we printed the NLRP3, I bought requests from Genentech and varied pharmaceutical corporations to go there and provides a chat on the mechanism so they may drugify. And I might throw up an enormous movement chart of all these mechanisms, and I feel they’d get annoyed. And it was like, ‘Properly, inform us the mechanism so we are able to make a drug out of this.’”
— Dr. Dominic D’Agostino
“I went on a trip the place I forgot melatonin and I slept like a child most likely as a result of I used to be up each morning. The solar is the final word circadian synchronizer. I bought off of melatonin to verify my endogenous melatonin, and there was no suppression.”
— Dr. Dominic D’Agostino
“So we went to those blue zones they usually simply, at night time after their dinner, the males will do a shot of alcohol, normally wine, however generally ouzo they usually’re all of their nineties and lots of, they’re within the blue zone. So it’s a common attribute.”
— Dr. Dominic D’Agostino
Wish to hear the final time Dom was on the present? Take heed to our earlier dialog through which we mentioned illness prevention, longevity, most cancers, ketogenic weight-reduction plan mastery, the detoxifying results of ketosis on pre-cancerous cells, learn how to jumpstart every day ketogenic cycles, “cheat” meals, and way more.