Ozempic Triggers Alarming Lengthy-Time period Well being Results, Physician Warns


  • Ozempic customers threat dropping important lean muscle and bone mass, making them bodily weaker and shortening their lifespan
  • GLP-1 medicine like Ozempic uninteresting emotional responses, scale back life satisfaction, and considerably improve dangers of melancholy and suicidal ideas by altering mind chemistry and dopamine regulation
  • After discontinuing semaglutide, many customers regain extra fats than they misplaced, with a worse fat-to-muscle ratio, as starvation returns and muscle loss stays unrecovered
  • Frequent GI signs may escalate into harmful circumstances like gastroparesis, the place digestion slows or halts, resulting in vomiting, nutrient deficiency, and persistent digestive misery
  • Since 2018, 62,000 hostile occasions and 162 deaths linked to Ozempic-type medicine have been reported, with a surge following elevated advertising and prescriptions after 2022

The recognition of glucagon-like peptide-1 (GLP-1) receptor agonists, similar to Ozempic and Wegovy, has considerably surged in recent times, with 1 in 8 Individuals now utilizing these medicine.1 Globally, round 20 million folks depend on semaglutide, the energetic ingredient in these injections, to assist with their weight reduction targets.2

However taking place this shortcut to attain your required weight truly comes with long-lasting results. Whereas these medicine are sometimes touted as a “miracle reply” for shedding kilos, consultants warn that taking them may trigger you to lose extra than simply physique fats — and expose you to dire, long-term penalties.

GLP-1 Receptor Agonists Alter Extra Than Your Waistline

In an article revealed within the Every day Mail, Benjamin Bikman, Ph.D., a metabolic scientist at Brigham Younger College in Utah, warns that GLP-1 receptor agonists are reshaping greater than physique weight — they’re altering your physiology, psychology, and probably your long-term well being trajectory as effectively.3

Three main results that Ozempic customers aren’t being informed about — In response to Bikman, Ozempic results in long-term results similar to extreme lack of muscle and bone, dulled emotional response that might result in melancholy, and fast rebound weight acquire that leaves sufferers with a worse fat-to-muscle ratio than earlier than.

You lose not simply fats, however lean muscle mass, too — The article notes one scientific trial on semaglutide, whereby 140 individuals had been tracked over 68 weeks and located that whereas they misplaced 23 kilos of fats, additionally they misplaced 15 kilos of lean muscle mass. That’s almost 40% of their complete weight reduction coming from tissue the physique truly must survive and thrive.

“Frail persons are more likely to die younger” — Bikman notes that having low muscle mass and fragile bones particularly amongst seniors, not solely places you prone to damage from falls; it additionally weakens your immune system, compromising your physique’s means to deal with infections, which can also be a typical well being concern among the many aged.

Ozempic Wrecks Your Psychological Well being

Bikman says that individuals who use Ozempic and Wegovy are additionally dropping their curiosity and want for sexual activity and social enjoyment. “The profit in lowering cravings for candy meals may very well be a discount in cravings for all times,” he warns.4 However to make issues worse, Ozempic wreaks havoc in your psychological state and leaves you feeling depressed.

Semaglutide medicine are related to an elevated threat of melancholy — He highlights one research whereby semaglutide customers developed a 195% elevated threat of main melancholy and over 100% better threat of suicidal habits in comparison with these on different medicines. In response to the researchers:

“These findings underscore the important want for physicians to completely assess affected person historical past earlier than prescribing GLP-1 RAs and spotlight the pressing requirement for additional potential scientific trials to totally perceive the implications of GLP-1 RA use on psychological well being within the overweight affected person inhabitants.”5

Ozempic customers are extra liable to having suicidal ideas — Bikman additionally notes further findings from a World Well being Group (WHO) database that exposed a forty five% increased price of reported suicidal ideas in sufferers utilizing semaglutide, in comparison with the typical throughout all medicines.

Why does Ozempic have an effect on your psychological state? Mainly, the drug’s major element targets GLP-1 receptors — these are current not simply in your digestive tract but in addition in important mind areas. These areas, such because the lateral septum and hypothalamus, are important for managing feelings, reward techniques and urge for food management.

Significantly noteworthy is its affect on dopamine — This neurotransmitter is intently related to temper regulation and reward notion. Analysis signifies that stimulating GLP-1 receptors enhances dopamine transporter expression, resulting in decreased free dopamine ranges in particular mind areas. This shift in dopamine signaling results in alterations in your temper, motivation ranges, and even the way you expertise pleasure.

Authorities companies insist there’s “no direct hyperlink” — Though the U.S. Meals and Drug Administration (FDA) and European Medicines Company (EMA) later concluded there wasn’t sufficient proof to substantiate a direct causal hyperlink, these early alerts are arduous to disregard.

In case you’re utilizing a drug that’s not simply flattening your urge for food but in addition crushing your motivation and skill to take pleasure in life, you’re more likely to wrestle extra with private progress, productiveness, and sustaining social bonds — all of that are foundational to your psychological well being.

The Ozempic ‘Rebound’ Downside

Lastly, Bikman says that utilizing semaglutide medicine truly results in extra weight acquire.6 He highlights a 2022 scientific trial involving roughly 200 long-term semaglutide customers; most regained about two-thirds of their misplaced weight inside a yr after stopping the drug7 — that is what’s known as the Ozempic rebound.

So why do you regain fats after stopping Ozempic? Merely put, if you’ve been taking Ozempic and out of the blue cease, the starvation cues it had suppressed come raging again — this causes you to revert to unhealthy consuming, which causes the load to return.

To place it merely, the muscle and bone mass you misplaced whereas utilizing this drug don’t return naturally; nevertheless, fats comes again simply and shortly. Semaglutide additionally triggers the formation of latest fats cells, in keeping with Bikman.

“This turns into an issue as a result of when an individual begin[s] to regain fats mass after stopping Ozempic, with extra fats cells comes a better potential to realize extra fats. ‘Consequently, despite the fact that an individual should still weight lower than they did earlier than beginning the drug, they could be fatter, with the next proportion of physique fats,’” he stated.8

Different “well being advantages” additionally disappear if you cease utilizing it — Ozempic is claimed to assist scale back blood stress, however this might bounce again if you discontinue utilizing the drug. There’s proof that sure optimistic cardiometabolic results persist; nevertheless, the positive factors are modest.

Sufferers have to be suggested to cease the drug after a interval of use — Throughout this time, they need to assess their cravings for carbohydrates. “Ideally, an individual has discovered learn how to eat higher and management carb cravings and their weight reduction might be sustained in the long term,” Bikman stated.

Abdomen Paralysis and Different Digestive Risks Linger Underneath the Floor

A separate report revealed in The Commonplace centered on one other rising concern, one which hasn’t obtained almost sufficient consideration — GLP-1 receptor agonists wreak havoc in your digestive well being.9

Ozempic interferes with regular digestion (and never simply in minor methods) — Whereas nausea, vomiting, constipation, and diarrhea are essentially the most generally reported digestive uncomfortable side effects, these signs may snowball into harmful, even life-altering issues, in keeping with well being consultants.

10% of GLP-1 drug customers expertise gastrointestinal disturbances — In some circumstances, these escalate into critical well being considerations. Kiran Jones, a scientific pharmacist at Oxford On-line Pharmacy, says essentially the most worrying amongst them is abdomen paralysis, or “gastroparesis.” This situation means meals strikes extraordinarily slowly — or by no means — by means of the abdomen. Left untreated, it causes persistent vomiting, malnutrition, and long-term digestive misery.

GLP-1 receptor agonists deliberately gradual digestion — This design goals to suppress your urge for food and hold you feeling full longer. Nevertheless, when overactivated, this identical mechanism will throw your complete digestive system out of steadiness.

Continual digestive points have a serious impression in your psychological well being — Fixed nausea, bloating, or ache disrupts your sleep, impacts temper, and will increase anxiousness. Over time, your confidence in your physique erodes.

There are different uncommon however extreme uncomfortable side effects linked to those medicine — Some customers have skilled kidney injury, pancreatitis, and even thyroid most cancers. Lately, I wrote an article concerning the many damaging results linked to those medicines, despite the fact that they solely result in “modest advantages.” Learn “Ozempic Linked to 19 Opposed Well being Occasions” for extra info.

Whereas The Commonplace article mentions cures that may assist curb the uncomfortable side effects of those medicine, like consuming crackers or sipping mint tea half-hour after taking the medicine, I consider the very best technique is to get off these medicine fully. There are higher and extra environment friendly methods to handle your weight with out harming your psychological and bodily well being.

Ozempic-Associated Deaths and Opposed Reactions Are on the Rise

From 2018 to 2024, the FDA Opposed Occasion Reporting System (FAERS), which tracks studies of hostile occasions associated to medicine like Ozempic, recorded 62,000 hostile reactions to semaglutide and tirzepatide (utilized in manufacturers like Mounjaro and Zepbound).10

Practically 75% of the hostile occasions occurred after 2022 — Round 46,000 hostile occasion studies coincide with the elevated availability and advertising of those medicine.

FAERS has recorded 10,000 “critical” reactions to those medicine — These are occasions that lead to hospitalization or life-threatening circumstances. These aren’t simply minor inconveniences; they’re important medical occasions that might have long-lasting impacts in your well being.

There have been additionally 162 reported deaths from these weight reduction medicine — In response to a Every day Mail article, the fatalities linked to those medicines elevated by 40% in simply six months. For extra info, learn “Ozempic and Different Weight Loss Medicine Linked to 162 US Deaths.”

In scientific trials, a staggering 80% to 90% of individuals skilled a minimum of one hostile occasion.11 Although most had been gentle to average, they led some folks to discontinue the medicine — which, if you happen to’re actually decided to be wholesome, is the step in the fitting path.

5 Methods to Tackle Underlying Metabolic Challenges

I consider the important thing to sustaining a wholesome weight is optimizing your mobile power manufacturing. This requires a multifaceted method that takes effort to implement, but it surely results in safer, more healthy outcomes — one thing GLP-1 receptor agonists don’t provide. Listed here are 5 methods that I like to recommend for wholesome weight administration.

1.Keep away from Ozempic and different GLP-1 agonist receptors — These medicines initially appear environment friendly in eliminating extra fats, nevertheless, their advantages are often short-lived and, as talked about above, the uncomfortable side effects (lots of that are nonetheless unknown) are damaging.

2.Get rid of vegetable oils out of your food regimen — In case you repeatedly eat ultraprocessed meals, I like to recommend stopping proper now and changing them with actual, complete meals. Processed meals comprise linoleic acid (LA)-rich vegetable oils that disrupt your metabolic pathways and alter how your physique shops fats. As an alternative, cook dinner your meals utilizing tallow, grass fed butter, or coconut oil.

3.Shift your carbohydrate sources progressively — Keep away from making sudden dietary adjustments that may shock your system. In case your intestine is compromised, begin by introducing simply digestible carbohydrates like complete fruit or white rice earlier than incorporating extra complicated carbs. In case you have extreme intestine points, sip dextrose water to offer your cells with a gradual supply of easy-to-digest, wholesome carbohydrates for power.

4.Take into account your protein and collagen consumption — I recommend aiming for 0.8 grams of protein per pound of your very best physique weight and balancing that quantity in order that about one-third comes from collagen. This can assist assist muscle upkeep, tissue restore, and hormone steadiness.

In case you train continuously, you would possibly must barely improve your consumption. My suggestion is to take it gradual and hearken to how your physique responds. Steady protein consumption is foundational for regulating cravings and stabilizing power.

5.Assist your mitochondrial well being with different wholesome habits — Getting each day solar publicity is one instance; nevertheless, if you happen to’re nonetheless consuming vegetable oils, be sure to keep away from intense noon solar for a minimum of six months.

The LA in these oils migrate to your pores and skin and oxidize underneath solar publicity, inflicting pores and skin injury. Get sufficient sleep at night time, decrease your stress, and incorporate moderate-intensity motion, similar to strolling, in your way of life — these methods will assist your mobile power manufacturing and assist in weight administration.

Gradual, constant effort in these areas strengthens your metabolism and results in lasting well being enhancements, together with attaining your optimum weight. Keep in mind, there is no such thing as a shortcut to optimum well being. In case you’re nonetheless tempted to start out utilizing weight reduction medicines, you owe it to your self to learn the research to grasp the risks.

Enhance Your GLP-1 Naturally with Akkermansia

Slightly than take weight reduction medicine, I like to recommend naturally boosting your GLP-1 ranges by supporting Akkermansia. This helpful intestine probiotic produces a GLP-1-inducing protein.

Many individuals lack Akkermansia attributable to varied causes — One motive is having impaired mitochondrial operate or an atmosphere that’s inhospitable to helpful intestine micro organism. Ideally, Akkermansia ought to comprise 3% to five% of your complete intestine microbiome and it performs many alternative roles other than selling GLP-1.

Akkermansia has the flexibility to provide mucin — This thick, gel-like substance that protects the intestine lining from dangerous pathogens, irritation from abdomen acid and enzymes, in addition to mechanical injury. Furthermore, mucin helps nourish the intestine micro organism already present in your intestine.

Sure meals will assist enhance your Akkermansia ranges — Polyphenol-rich fruits like berries and inulin-rich meals similar to garlic, asparagus, bananas, and leeks will assist improve your Akkermansia ranges.

Notice, nevertheless, that in case your intestine well being is presently out of whack, introducing excessive quantities of dietary fiber in your system all of sudden may worsen your gastrointestinal signs. So, work on therapeutic your intestine first, then progressively improve fiber consumption.

Dietary supplements are additionally accessible — Ideally, search for Akkermansia merchandise that use timed-release capsules or microencapsulation expertise to make sure it reaches your colon successfully. Right here’s how to ensure Akkermansia reaches your colon.

It’s additionally vital to get rid of all vegetable oils out of your food regimen for a minimum of six months earlier than beginning an Akkermansia supplementation program. This preparatory interval permits your physique to recuperate mitochondrial operate and create a extra hospitable atmosphere in your colon for the helpful micro organism.

Regularly Requested Questions (FAQs) About Ozempic Aspect Results

Q: What are essentially the most regarding long-term uncomfortable side effects of Ozempic and comparable medicine?

A: Ozempic, Wegovy, and different GLP-1 receptor agonists might trigger extreme lack of muscle and bone mass, dulled emotional responses, and rebound weight acquire that worsens physique composition. These adjustments may considerably impression long-term bodily and psychological well being.

Q: How do GLP-1 medicine like Ozempic have an effect on psychological well being and emotional well-being?

A: These medicine alter mind areas tied to temper and pleasure by lowering dopamine ranges, growing the danger of melancholy, emotional numbness, and even suicidal ideas. Some customers report a lack of curiosity in intimacy, meals, and social connection.

Q: Why do folks typically regain weight after stopping Ozempic?

A: After discontinuing Ozempic, urge for food suppression wears off quickly, typically resulting in overeating. The misplaced muscle and bone mass don’t return naturally, however fats does — resulting in a worse fat-to-muscle ratio and better long-term weight acquire threat.

Q: Are there any critical digestive or bodily issues related to these medicine?

A: Sure. Past frequent signs like nausea or constipation, some customers develop critical circumstances like gastroparesis (abdomen paralysis), kidney injury, pancreatitis, and even thyroid most cancers. Continual GI points additionally have an effect on temper, sleep, and total high quality of life.

Q: What are safer alternate options to attain sustainable weight reduction and metabolic well being?

A: Keep away from GLP-1 medicine and focus as an alternative on eliminating vegetable oils, progressively enhancing carbohydrate high quality, growing protein and collagen consumption, supporting mitochondrial well being by means of way of life adjustments, and boosting pure GLP-1 through Akkermansia probiotics.



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